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Chicken Bubble Biscuit Bake Casserole

A comforting and family-friendly casserole made with tender chicken, creamy sauce, and fluffy biscuits, perfect for any night of the week.
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Prep Time 15 minutes
Cook Time 35 minutes
Total Time 50 minutes
Servings: 6 servings
Course: Dinner, Main Course
Cuisine: American, Comfort Food
Calories: 425
Ingredients Method Notes

Ingredients
  

Chicken Casserole Filling
  • 2 cups cooked chicken (shredded or diced, rotisserie works great) You can use leftover chicken for quick preparation.
  • 1 can (10.5 oz) cream of chicken soup (or cream of mushroom soup) Choose your favorite cream soup.
  • 1/2 cup sour cream (or plain Greek yogurt) For a lighter option, use Greek yogurt.
  • 1/2 cup milk Any milk variety works.
  • 1 cup frozen mixed vegetables (peas, carrots, corn, beans) Feel free to add fresh veggies.
  • 1 tsp garlic powder For added flavor.
  • 1/2 tsp onion powder Enhances the taste.
  • to taste Salt and pepper Adjust according to preference.
  • 1 can (16 oz) refrigerated biscuit dough, cut into quarters Use gluten-free biscuit dough if needed.
  • 1 cup shredded cheddar cheese (or mozzarella cheese) Experiment with different cheese varieties.
  • 1 tbsp melted butter (optional, for brushing) Adds sheen to the finished casserole.

Method
 

Preparation
  1. Preheat your oven to 350°F (175°C) and lightly grease a 9×13-inch baking dish.
  2. In a large bowl, combine the cooked chicken, cream of chicken soup, sour cream, milk, frozen mixed vegetables, garlic powder, onion powder, salt, and pepper. Stir until smooth and well combined.
  3. Gently fold in the quartered biscuit pieces, ensuring they are fully coated in the mixture.
  4. Pour the chicken mixture into the prepared baking dish. Sprinkle the shredded cheese evenly over the top.
  5. Cover with foil and bake for 20 minutes. Remove the foil and continue baking for an additional 10-15 minutes until the biscuits are puffed, golden, and fully cooked.
  6. If desired, brush the top with melted butter for a lovely sheen. Allow the casserole to cool slightly before serving.

Notes

To elevate your casserole experience, swap in different meats or veggies, add spices or herbs, and make ahead by preparing the filling in advance.